The Ti48Al2Cr2Nb(Ti4822) alloy specimens were processed by electron beam melting (EBM) technique and heat-treated. The microstructure and mechanical properties of the alloy were investigated by ultra-depth microscope, scanning electron microscope, X-ray diffractometer and microhardness tester. The kinetics of microstructure transformation was also analyzed. The EBM-formed Ti4822 alloy undergoes an α→γ transition after heating to 1360 ℃ and holding at 1220–1280 ℃. With the decrease in holding temperature, the transformation rate gradually increases, and the transformation of equiaxed γ phase increases from 20.01% to 53.32%. As the holding time increases from 5 min to 180 min, the transition rate first increases and then decreases. The kinetic relationship of the α→γ transition could be predicted using the Avrami equation: , for which k varies from –1.94×10^-3 to –21×10^-3 and n varies from 0.38 to 0.53. The microhardness of alloys held at 1280 ℃ is tested for different times, and that of alloy specimen held for 5 min reaches 506 HV_0.1.