Titanium alloys with high strength and toughness are the backbone material for manufacturing super-standard aeronautical structures. In present research, High temperature deformation behavior of the Ti-4.5Al-6.5Mo-2Cr-2.6Nb-2Zr-1Sn Ti-alloy has been investigated by thermal simulation compression experiment. The critical condition dynamic model was used to establish the prediction model of dynamic recrystallization volume fraction during hot deformation processing. The results obtained in this study will provide an effective theoretical support for the integrated manufacturing of key structural components with super-large size and complex shape.