Macrosegregation is a typical defect occurred during the vacuum arc remelting (VAR) of titanium alloy ingot. In the subsequent heat treatment serious segregation of special elements would lead to the so called beta-fleck, which will significantly reduce the property of product. Reducing the incidence of macrosegregtion requires a thorough understanding of the formation mechanism of such defect. In this paper a continuum model for alloy solidification has been used to simulate the temperature evolution, solute distribution and liquid flow. The segregation patterns obtained in simulations are consistent with the observations in experiments. The development of segregation in the conditions with different thermal and solute buoyancy forces were analyzed. It was shown that the inhibition of flow can minimize the macrosegregation to the greatest extent. It was also found that the solute partition coefficient determines the segregation pattern and severity in the same fluid flow conditions.