In present work, a new type of bulk metallic glass quaternary alloy, Zr51Al9.96Ni14.34Cu24.7, was designed by using binary eutectic clusters method. The new alloy displays a high strength up to 2356 MPa and a large plastic strain of 14.6% at room temperature according to compression test. The excellent ductility of the present glassy alloy is attributed to the deformation to induce the nanocrystalline, which can induce the formation of numerous new shear bands and enhance the density of shear bands; on the other hand, to influence the propagation of shear bands to intersect and to branch during deformation process, as a result, the plasticity of alloy is improved.