Insufficient bond strength between ceramic and titanium restricts their application in clinic. The attempt of the present study is made to introduce a concept of the titanium alloy with low elastic modulus for simulating and investigating different destroying conditions such as shear load at metal-ceramic interface, middle bending load etc. The results indicate that the interface stress level of titanium alloy with low elastic modulus is 6% lower than that of pure titanium when the alloy is subjected to shear load. On the condition of being subjected to middle bending load, the thickness of titanium alloy substrates of low elastic modulus should be increased to obtain better match between stiffness and stress distribution, which could be well satisfied in clinic (thickness>2 mm).