Zr1-xTixNiSn0.975Sb0.025 (x=0, 0.15, 0.25, 0.5) based Half-Heusler thermoelectric materials were synthesized by suspension melting. X-ray diffraction results show that the obtained alloy was single phase compound. Compared with conventional melting methods, the suspension melting markedly reduced the preparation duration. Meanwhile the effects of Ti substitution and different hot-pressing conditions on thermoelectric properties of the materials were also studied. Results show that the Ti substitution for the A site of ZrNiSn0.975Sb0.025 can reduce the thermal conductivity but does not affect its thermoelectric properties obviously. The density can affect the thermoelectric properties. Proper hot-pressing condition can make ZT values reach the maximum of about 0.45.