The effect of hydrogenation on the microstructure and properties of TC21 alloy by die forming and sintering using hydrogenated powder to produce titanium alloy was researched by means of the room-temperature die forming and sintering in a protection atmosphere. The results show that the TC21 titanium sintered body using hydrogenated powder with hydrogen content of 0.39 wt% by die forming and sintering has a thinner microstructure and higher density, compression strength and compressive yield strength than the others. With hydrogen content increasing, the sheet microstructure gets thinner and finer and the grain size becomes smaller and homogeneous with safe hydrogen content. As a conclusion, the hydrogen content of 0.39wt% is the best for the TC21 titanium alloy sintered body according to the density and mechanical property.