The medical Ti-Mo alloys were fabricated by powder metallurgy. The effects of different process parameters on the phase, the morphology and the mechanical properties of Ti-Mo alloys were investigated through X-ray diffraction (XRD), scanning electron microscopy (SEM) and mechanical properties test methods. The results show that after sintering at 1050 °C, the microstructure of Ti-Mo alloys mainly consists of β phase. By adjusting the pressure, sintering time and Mo contents to regulate the porosity of Ti-Mo alloy and α→β phase transition, thus the flexural strength and the elastic modulus of Ti-Mo alloys can be controlled