It is of great value for the control and optimation of titanium alloy''s properties by establishing its microstructure-tensile property relationship. Based on quantitative metallography and Stereology, the quantitative relationship between microstructure and tensile property for Ti-6Al-4V alloy with basket-weave structure is establised using multielement non-linear regression in present paper. In this model, the independent variables including lamellar α phase’s thickness and lamellar α phase’s aspect ratio, and the dependent variables are Ti-6Al-4V alloy’s tensile properties. Results show that the multiple regression model built in present paper can precisely describe the microstructure-tensile property relationship of Ti-6Al-4V alloy with basket-weave structure, which indicates that the mehod of establishing model used in present paper is applicable.