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钛基表面TiO2-HA生物陶瓷膜层的血液相容性研究
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江苏大学机械工程学院,常州大学,江苏大学机械工程学院,江苏大学实验动物中心,江苏大学实验动物中心

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R138

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江苏省高校自然基金重大项目(11KJA430004),江苏省高校自然基金(12KJD460002)项目(1291110038)资助


Blood Compatibility of TiO2-HA Bioceramic Coating on Titanium
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School of Mechanical Engineering,Jiangsu University,,School of Mechanical Engineering,Jiangsu University,Laboratory Animal Research CenterS,Jiangsu University,Laboratory Animal Research CenterS,Jiangsu University

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    摘要:

    采用微弧氧化法及微弧氧化-水热法对纯钛进行改性,制备了TiO2与TiO2-HA生物陶瓷膜层,通过溶血率实验、动态凝血时间实验和血小板黏附实验等方面评价其血液相容性。研究结果表明:各试样的溶血率都远小于5%,均符合医用材料的溶血率要求,不会产生溶血作用。与钛基TiO2生物陶瓷膜层和钛基材相比,钛基TiO2-HA生物陶瓷膜层的溶血率更低,动态凝血时间曲线变化更为缓慢,黏附的血小板更少,且变形程度更轻,具有更好的抑制血小板的聚集与变形的性能,血液相容性更优。

    Abstract:

    Modified titanium materials, including TiO2 and TiO2-HA bioceramic coatings, were prepared by micro-arc oxidation and micro-arc oxidation-hydro-thermal methods. Determination of the hemocompatibility of the coatings through a hemolysis experiment, dynamic clotting time test, and platelet adhesion experiment was also performed. The results demonstrated that: Hemolysis rates of all samples were less than 5%, no hemolysis was observed. Compared with titanium and TiO2 bioceramic coating of titanium, TiO2-HA bioceramic coating of titanium exhibited lower hemolysis rate, slower change in dynamic clotting time and less platelet adherence. The proposed TiO2-HA bioceramic coating further showed a lower degree of deformation, better inhibition of platelet aggregation and deformation, and excellent hemocompatibility.

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徐琳,丁建宁,许晓静,何远清,雷小春.钛基表面TiO2-HA生物陶瓷膜层的血液相容性研究[J].稀有金属材料与工程,2017,46(5):1299~1304.[Xu Lin, Ding Jianning, Xu Xiaojing, HeYuanqing, Lei Xiaochun. Blood Compatibility of TiO2-HA Bioceramic Coating on Titanium[J]. Rare Metal Materials and Engineering,2017,46(5):1299~1304.]
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  • 收稿日期:2015-01-15
  • 最后修改日期:2015-03-06
  • 录用日期:2015-05-13
  • 在线发布日期: 2017-09-27
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