Considering of the relationship between meso-scale accumulated damage and microstructure, external cyclic strain load was applied on 2D representative volume element (RVE) of CuW alloys, and the accumulated damage and induced crack behaviors of CuW alloy were stimulated utilizing Darveaux model. The results show that the plastic slip bands appear on the copper phase at the beginning, damage and induced cracks of CuW alloy initiate at the corners and then propagate along and edges of tungsten grains with the increase of cyclic number, the propagation path of micro-cracks is affected by the distribution of tungsten grains mainly, while the sintering necks lower the propagation speed of micro-cracks on some extents.