The complex-shaped Ti-6Al-4V alloy is widely used in the aerospace engineering and automobile industry. However, because of its high hardness, easy adhesion, large dimension and high precision, it is a great deal of cost of raw materials, and besides, it is difficult to machine unless it uses special cutting tools by the traditional manufacturing methods. In this study, a closed isothermal forging process was adopted for precision forming of the wing. The rational billet shapes were estimated by flow simulation experiment, and then mechanical property, forming ability, process parameters of the Ti-6Al-4V wing were studied by the isothermal forging tests to meet performance targets. The results show that, compared with the titanium wing formed by conventional methods, the wing made by isothermal forging remarkably improved mechanical performances, and material utilization was reaching from 13% to 50%. During the isothermal forging process of Ti-6Al-4V, the flake α grains at 950℃ was transformed to β grains in the matrix; while the progress of transformation diminished when the forging temperature decreased to 900℃.