In this study, a biomedical β-Ti alloy Ti?25Nb?3Zr?3Mo?2Sn (wt. %) was fabricated via spark plasma sintering (SPS) its prealloyed powder. The prealloyed powder was produced by a plasma rotating electrode process. The majority of the powder particles had a microstructure composed of β-phase predominant dendrites, while a small fraction of the powder particles had a single crystal microstructure. SPS with a condition of 1000℃/5min/50MPa could just completely densify this β-Ti alloy powder and remove its prior dendritic segregation. After solution treatment, the consolidated alloy had a microstructure consisting of α″ + β phases, and exhibited a good tensile strength of 815 MPa and an optimal elongation of 14%, as well as a low elastic modulus of only 62 GPa. Aging at 500 ℃ brought about high number density of pure nanosized α needles, which renders this alloy a superior tensile strength up to 1015 MPa along with elongation and elastic modulus both acceptable. However, excessively low aging temperature should be avoided, due to the sharp embrittlement induced by nanoscale ω-phase precipitates.