FGH97 nickel-base superalloy were processed at different solution cooling rates, then the microstructure and creep behavior of FGH97 nickel-base superalloy were studied by optical microscope, scanning electron microscope, energy disperse spectroscopy and creep testing machine. The results show that the grain size decreases, the size of γ′ precipitates decreases and the carbide precipitates change from continuous to discrete with the increasing solution cooling rate, and GB carbides are composed of (Ti, Nb, Hf)-rich. The creep performance of the alloy with a solution cooling rate of 94 ℃/min was significantly better than that with a cooling rate of 43 ℃/min under 750℃/450MPa.γ′ cutting is the deformation mechanism of FGH97 alloy under 750℃/450MPa, stress concentration at grain boundary leads to initial cracks, then crack propagates along grain boundary and finally leads to fracture. The disperse distribution carbides on grain boundary can inhibit the propagation of microcracks.