In this paper, numerical simulation technique and experimental study were used, and the effects of different process parameters on the properties of the products of unidirectional asynchronous rolling of magnesium alloy plate are analyzed. We also used ANSYS/LS-DYNA finite element software to complete the numerical simulation and carried out the experimental study of unidirectional asynchronous rolling under different rolling conditions. Besides, the internal structure was observed by metallographic microscope, and the yield, tensile and hardness properties of magnesium alloy plate were tested by tensile testing machine and micro vickers hardness tester.