The hot deformation behavior of explosive welded titanium-aluminum (Ti-Al) clad plate was studied by isothermal compression tests at 300~500 °C with strain rates of 0.1~10 s^-1 on Gleeble 3500 simulated machine. The hot processing map was developed on the basis of experimental data using the principles of dynamic materials model, and the verification experiment of hot rolling process of Ti-Al clad plate was carried out based on the hot processing map. The results show that Ti-Al clad plate is a kind of positive strain rate sensitive material. The efficiency of power dissipation of 0.64~0.72 can be observed at 420~460 °C with strain rate of 1.6~6.3 s^-1 in the hot processing map, and the process parameters of this region are suitable for the hot rolling of Ti-Al clad plate. After hot rolling, the interfaces of the Ti-Al clad plates are well bonded, and the plates have excellent mechanical property and good sheet metal forming property. The deformation mechanism of Ti-Al clad plate in the hot rolling process is as follows: the Al layer with low deformation resistance and fast flow can produce plastic deformation, and at the same time it can pull the Ti layer together to produce plastic deformation; in this process, the Al layer is hot deformation while the Ti layer is cold deformation.