GH4151 is a new type of wrought superalloy used in the manufacturing of aero-engine turbine discs. This alloy has a high level of strengthening elements, complex solidification behavior, and a high cracking tendency, making it difficult to produce ingots with large-size. In this paper, a 2-ton GH4151 alloy ingot with a diameter of 508 mm was prepared by the triple melting process. The solidification structure of the ingot was analyzed, and the composition uniformity of the ingot was evaluated. Industrial experiment showed that a crack free ingot could be obtained, and the secondary dendrite arm spacings from the ingot edge to the center were 80 μm and 150 μm, respectively. The composition at the top and bottom of the ingot showed a good uniformity in transverse sections. The variation range for elements Co, Cr, W, and Mo was within 0.05 wt.%, and the variation range of the Nb element was lower than 0.07 wt.%. However，the variation for Al and Ti were relatively large, due to the melting loss in the axial direction. After homogenization, the segregation coefficients of the alloying elements could be controlled between 0.8 and 1.2. Alloy bars with a diameter of 300 mm were prepared through homogenization and forging. The microstructure, properties, and flaw detection of the bars could meet the technical requirements, verifying that the prepared ingot is of satisfactory metallurgical quality.