In this paper, a series of Zr-M (M=B, Si, Sn, V, etc.) alloys were prepared according to the atomic ratio of 98:2. The microstructure, pitting corrosion behavior and corrosion resistance of Zr-2M alloys were systematically studied by XRD, EBSD, SEM, XPS and electrochemical tests. The Zr-2M alloys were analyzed from three aspects: microstructure and composition of passive film, grain refinement and phase composition. The results show that: The addition of alloying elements had a significant refinement effect on the microstructure of Zr-2M alloys. Grain refinement could improve the corrosion resistance of Zr-2M alloy, but the effect on pitting corrosion resistance was different; The second phase was precipitated in the Zr-2M alloys. The existence of the second phase will cause local stress in the passive film and destroy the stability of the passive film, which will lead to the decrease of corrosion resistance; The semiconductor type (n/p type) of the oxide in the passive film is closely related to the structure and compactness of the passive film.