The microstructure of TC18 titanium alloy die forging shows delamination. The brighter microstructure has lower performance and is often called cold die microstructure. Decreasing the cooling rate could hinder the generation of the cold die microstructure, but it may also enlarge the die wear. The balance relation between microstructure delamination of a TC18 frame forging and the die wear in different parameters was studied in simulation and experiment. The programs to predict the cold die microstructure and wear depth were built and realized by secondary development. The continuous forging production process was simulated by deform-3d and the characteristics of cold die microstructure and wear were researched. The balance relationship between the die wear and the cold die microstructure content in different parameters was discussed by the response surface method and the optimal parameters. The research has great significance to both forging qualities controlling and die life increasing.