In recent years, the researches on the mechanical behavior of high-entropy alloys with cubic structure at cryogenic temperature (77K) have become a hot topic. It is found that stacking fault energy (SFE) of some cubic high-entropy alloys decreases with the decrease of temperature. Compared with that at room temperature, the mechanical properties of these alloys at cryogenic temperature show remarkable increase, suggesting their tremendous potential as promising structural materials used at cryogenic-temperature. In this paper, recent progress on the mechanical behavior of high-entropy alloys with cubic structure at cryogenic temperature are reviewed systematically, focusing on the underlying mechanisms of strengthening and toughening during plastic deformation. At last, the possible future development trend is also given.