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    Abstract:

    Improving the degradation rate and bioactivity of magnesium in physiological environment is helpful to its application in biomedical field. Alloying treatment and surface modification are two effective ways. In the present study, a novel surface modification strategy, i.e. graphene oxide / hydroxyapatite / magnesium hydroxide (GO/HA/Mg(OH)2) composite coating constructed on the surface of magnesium-calcium alloy by the combination of hydrothermal treatment, electrophoretic deposition and electrochemical deposition, was proposed for magnesium-calcium alloy (ZQ). Scanning electron microscope (SEM) and X-ray diffraction (XRD) analysis confirmed that the surface of the coating sample (ZQ-HEP) was composed of outer nano-sheet HA, middle flocculent-lamellae GO and inner Mg (OH)2 nano-sheet. The electrochemical corrosion resistance test in vitro showed that comparing with the untreated ZQ, ZQ-HEP had higher corrosion resistance in phosphate buffer solution (PBS). A rabbit femoral condyle fracture model was constructed to evaluate the fracture repair effect of ZQ samples before and after surface modification. Postoperative gross observation, radiograph and histological analysis confirmed that comparing with the untreated ZQ, ZQ-HEP screws could decrease the hydrogen release obviously and thus the subcutaneous emphysema after implantation into the body. Meanwhile, due to its higher corrosion resistance and bioactivity, ZQ-HEP screw could maintain its integrity better than the ZQ one at 4 weeks postoperatively, and induce more new bone growth. Therefore, more rapid fracture healing was observed on ZQ-HEP than ZQ. In conclusion, the multi-functional coating construction strategy proposed in current study could have good prospect of clinical application. It can not only regulate the degradation rate of medical magnesium metals, but also significantly improve their osteogenic ability.

    Reference
    [1]Liu L, Yang Q, Huang L et al. Applied Surface Science [J], 2019, 484(AUG.1):511-523
    [2]Khazeni D, Saremi M, Soltani R. Ceramics International[J], 2019,45:11186-11194
    [3]Wan Y, Xiong G, Luo H et al. Materials Design[J], 2008, 29(10):2034-2037
    [4]Eslami H S, Mohammad M, Shahriar K et al. Materials Research[J], 2013, 16(1):11-18
    [5]Salahshoor, Guo, Yuebin. Materials[J], 2012, 5:135-155
    [6]Hornberger H, Virtanen S , Boccaccini A R. Acta Biomaterialia[J], 2012, 8(7):2442-2455
    [7]Agarwal S, Curtin J, Duffy B et al. Materials ence and Engineering: C[J], 2016, 68(nov.):948-963
    [8]Jeong H, Yoo Y. Surface and Coatings Technology[J], 2015
    [9]Zhu Y, Zhao Q, Zhang Y H et al. Surface Coatings Technology[J], 2012, 206(11-12):2961-2966
    [10]Tang H, Wang F. Materials Letters[J], 2013, 93(FEB.15): 427-430
    [11]Shang W, Zhan X, Wen Y et al. Chemical Engineering Science[J], 2019, 207:1299-1308
    [12]Harada Y, Kumai S. Surface Coatings Technology[J], 2013, 228:59-67
    [13]Gao F, Hu Y, Gong Z et al. Materials ence and Engineering: C[J], 2019, 104:109947
    [14]Kumar, Alok, Joddar et al. Materials science engineering, C[J], 2017, 73:788-797
    [15]Khiabani A B, Rahimi S et al. Materials Today[J], 2018, 5: 15603-15612
    [16]Gao F, Hu Y, Gong Z et al. Materials ence and Engineering: C[J], 2019, 104:109947
    [17]Rau J V, Antoniac I, Filipescu M et al. Ceramics International[J], 2018, 44:16678-16687
    [18]Jamesh M, Kumar S, Narayanan T S N S. Journal of Coatings Technology and Research[J], 2012, 9(4): 495-502
    [19]Song Y W, Shan D Y, Han E H. Materials Letters[J], 2008, 62(17-18):3276-3279
    [20]Bita A I, Semenescu A, Antoniac A et al. Key Engineering Materials[J], 2016, 695:152-156
    [21]ShiCheng, WanshunWang, DonghuiWang et al. Biomaterials ence[J], 2020, 8: 3320
    [22]Gao F, Xu C, Hu H et al. Materials Letters[J], 2015, 138(jan.1): 25-28
    [23]Qureshi W, Kannan S, Vincent S et al. Iop Conference[J], 2018, 346:012012
    [24]Zou Y H, Jian W, Cui L Y et al. Acta Biomaterialia[J], 2019, 98: 196-214
    [25]Zhou X, Fu X, Chen H et al. Journal of Materials Chemistry B[J], 2019
    [26]Bakhsheshi-Rad H R, Hamzah E, Tok H Y, et al. Journal of Materials Engineering Performance[J], 2017, 26(2):653-666
    [27]Wang G, Jiang W, Mo S et al. Advanced Science[J], 2020, 7(1)
    [28]Zhang Y, Chen F, Zhang Y et al. Tribology International[J], 2020, 146:106135
    [29]Chaya A, Yoshizawa S, Verdelis K et al. Acta Biomaterialia[J], 2015, 18: 262-269
    [30]Han P, Cheng P F, Zhang Z X et al. Biomaterials[J], 2015, 64: 57-69
    [31]Fu X, Zhou X, Liu P et al. Regenerative biomaterials[J], 2020
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[Chen Hewei, Yuan Bo, Wang Linnan, Yang Xi, Zhu Xiang Dong, Song Yueming, Zhang Xingdong. Corrosion resistance and fracture repair ability of magnesium-calcium alloy with hydroxyapatite/graphene oxide/magnesium hydroxide composite coating[J]. Rare Metal Materials and Engineering,2021,50(10):3698~3706.]
DOI:10.12442/j. issn.1002-185X.20200809

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History
  • Received:October 20,2020
  • Revised:November 22,2020
  • Adopted:December 23,2020
  • Online: October 28,2021
  • Published: October 25,2021