To investigate microscopic microstructural damage of porous W/Zr-based metallic glass composite, the microscopic-scale finite element model of the composite was established based on their scanning electron microscope images, and the quasi-static compression process of the composite was numerically simulated in conjunction with the cohesive zone model. The effects of interface stiffness, interface strength and fracture energy on the mechanical properties of the composite were investigated, and the values of cohesive zone model parameters were determined by comparing them with quasi-static compression experimental data. Results show that there are three damage modes of porous W/Zr-based metallic glass composite during compression process, which are cleavage fracture of the W particle, shear band fracture within the Zr-based metallic glass and interfacial crack between the two phases. The cohesive zone model parameters have a great influence on the simulation curve: the greater the interface stiffness, the higher the slope of the simulation curve; the greater the interface strength, the higher the yield point of the simulation curve; the larger the fracture energy, the shorter the plastic stage of the simulation curve. As the interface stiffness, interface strength and fracture energy are taken as 10 000 GPa/μm³, 500 MPa and 0.055 J/m², respectively, the simulation results are well consistent with the experimental results, and the simulation model is able to accurately describe the mechanical behavior of porous W/Zr-based metallic glass composite.