The fretting wear characteristics of Titanium alloy TC11 in seawater are studied by a SRV wear machine. The effects and the lubrication media on the friction coefficient and the wear resistance are investigated. Results show that the friction coefficients turn stable with the increase of amplitude, and the volume-losses increase with the increase of the amount and amplitude of load. The wear mechanism is fatigue and peeling with grain abrasion for small amplitudes, and only grain abrasion for big amplitudes. Compared with in pure water, the friction coefficient decreases greatly even to 50% in seawater with a smaller volume-loss, exhibiting a negative interaction between corrosion and wear.