Lanthanum-doped molybdenum powder was prepared by a liquid-liquid doping method and sol-gel technique, and then the lanthanum-doped molybdenum billet was obtained by isostatic pressing and sintering. The microstructure, morphology and RE phases of the materials in different states were analyzed using XRD, SEM, EDS, TEM etc. The results show that a chemical reaction between La(NO3)3 and (NH4)6Mo7O24·4H2O generates La2(MoO4)3. After calcination and reduction, RE phase exists in the molybdenum powder in the form of La2O3 and can refine the powder particles. La2O3 distribute dispersively in the molybdenum matrix after sintering into a billet