Using the model of cluster + glue atom, the ternary bulk metallic glasses (BMG) in Fe-B-Y system was designed, choosing the close-packed Archimedes octahedral antiprism CN-10 Fe8B3 as basic cluster and Y as glue atom. 3at%Nb was added as minor alloying element to form quaternary BMG. Ni was used to substitute for Fe, and a quinary BMG, [(Fe100-xNix)8B3-Y]97-Nb3, was formed. Results show that when Ni is less than 30at% the BMG with diameter of 2 mm can be obtained and the alloy [(Fe94Ni6)8B3-Y]97-Nb3 has the biggest Tg, Tx and Trg which are 884 K, 972 K and 0.634, respectively.