A hydrophobic Ti6Al4V (TC4) titanium alloy with muti-level roughness surface was fabricated with micro-arc oxidation and hydrothermal reaction, combined with fluorination treatment. Fourier transform infrared spectroscopy, energy dispersive spectroscopy, and field emission scanning electron microscopy (FESEM) were used to characterize the surface structures and compositions of the materials. Water contact angle measurement was used to measure the surface wetting property of the modified TC4 as well. Therefore, the construction of a superhydrogphobic surface was successfully achieved by multilevel roughness structures and low surface energy treatment. Furthermore, the platelets adhesion and hemolysis assays suggested superior hemocompatibility of the TC4 surface after modification. Corrosion resistance tests before and after surface modification of the material indicated that the superhydrophobic structures on the TC4 surface could effectively reduce the contacting space between the interface of materials and the corrosive fluid and blood components, thereby weaken the interaction between material surface and the blood cells, such as platelets and red blood cells, and meanwhile could greatly improve the corrosion resistance of TC4.