As an important nuclear fuel, γ-U alloys with the body centered cubic(BCC) structure have high temperature stability and comprehensive performance among Uranium alloys, which are the target of recent alloys design. In the present paper, cluster-plus-glue-atoms structure model, which used to describesolid solution alloys, are applied to build the component formulas of γ-U solution alloys, and clarify that the structural unit of γ-U alloys is composed by BCC first neighbor coordination polyhedron cluster and three glue atoms. Further, an enormous amount of the existing alloy components are analyzed based on the model, which shows that all the BCC-stable alloys satisfy the model, such as [Mo-U14]Mo3(U-10.7Mo), [Zr-U14]Nb3(U-7.5Nb-2.5Zr, i.e., Mulberry alloy), which are all exhibit best structural stability in their respective systems and show excellent corrosion resistance. Therefore, the component design method based on cluster-plus-glue-atoms model clusters has important guiding value on predicting alloys composition and performance.