In view of the characteristics of narrow hot rolling temperature range, rapid temperature drop and large deformation resistance of titanium alloy , titanium alloy and the new technology of seamlessStube Tandem Skew Rolling was combined and systematic research was carriedSout in this paper. According to the process structure and characteristics, the speed model, tension model and rolling force model of TSR were described,the deformation mechanism and the metal flow law of titanium alloy in TSR process was studied by finite element numerical simulation,the distribution of stress and strain field, temperature field and velocity field were obtained, and the field test was conducted based on finite element simulation. The results show that when the temperature is 1050℃ and the parameters of the piercing section and rolling section are matched reasonably, the seamless titanium alloy tube can be successfully obtained with high dimensional accuracy and no obvious surface defects. The theory and experimental analysis show that the TSR process is completely suitable for the preparation of seamless titanium alloy tube, and the production process is shortened and the production efficiency is improved.