TC4,Ti6242 and TA15 titanium alloy ingot were prepared by one-time smelting using an electron beam cold-bed melting furnace( EB furnace). A brief numerical analysis of the volatilization law of Al,Sn,Zr and Mo elements was studied by Langmuir's law,which was compared with the actual volatility law. The results show that in the EB melting process of TC4,Ti6242,TA15 titanium alloys,the volatilization ratio of Al in the three alloys is different,and the order of volatilization ratio is TC4 > Ti6242 > TA15. Al is the main volatile element of TC4 titanium alloy.The problem of joint volatilization exists between Al and Sn elements in Ti6242 titanium alloy. In TA15 titanium alloy,there is also a problem of joint volatilization between Al and Zr elements,and the volatilization of Al element drives the volatilization of Zr element( hard-to-volatile element).